The administration of vasoactive drugs is of great importance in intensive care units. They are primarily used in hemodynamically unstable patients with the aim of stabilizing blood pressure, cardiac output, and consequently ensuring adequate tissue perfusion. Vasoactive drugs should be introduced into therapy in patients with an inadequate response to oxygenation, ventilation, and fluid resuscitation. These include vasopressors, which have a pronounced vasoconstrictive effect, while drugs with inotropic effects act on cardiac function. The choice of vasoactive drugs in therapy depends on the patient's condition and the etiology of the hemodynamic instability. Some conditions that require support with vasoactive drugs include septic shock, cardiogenic shock, heart failure, cardiopulmonary resuscitation, anaphylactic shock, etc. The administration of vasoactive drugs requires continuous monitoring of hemodynamic functions such as blood pressure, cardiac output, and heart rate, as well as laboratory values and clinical signs to avoid complications and ensure therapeutic effectiveness. Drug dosages are often titrated according to the clinically visible effect to avoid side effects such as myocardial ischemia or arrhythmias. The successful administration of vasoactive drugs relies on the expertise of the medical team, ongoing patient monitoring and adherence to protocols.