Objectives: The aim of this study was to investigate correlation between disease activity and pregnancy outcome in patients with systemic lupus erythematosus. Furthermore, the aim was to investigate correlation between lupus nephritis, hypertension and antiphospholipid antibodies with pregnancy outcome in patients with systemic lupus erythematosus. Study design: cross-sectional study Participants and Methods: The study included 14 patients of the Institute for Rheumatology, Clinical Immunology and Allergies of CHC Osijek with diagnosed systemic lupus erythematosus who were pregnant between January 2009 and December 2018. There were 21 pregnancies recorded. The data was collected from the medical records. Fisher's exact test and McNemar test were used for the statistical data processing. The statistical significance was set at α = 0.05. Results: The median age of pregnant women is 30 years. The systemic lupus erythematosus activity and positive antiphospholipid antibodies significantly decreased prior to the pregnancy according to the values of anti-dsDNA (p = 0.008), C3 (p = 0.02), C4 (p = 0.02), aCL (p = 0.02) and LAC (p = 0.02). The most commonly prescribed medications for pregnant women were glucocorticoids. The following pregnancy outcomes were determined: 10/21 in-term deliveries, 7/21 premature deliveries, 2/21 intrauterine growth retardation, 1/21 miscarriage, and 1/21 stillborn. Conclusion: The activity of systemic lupus erythematosus during pregnancy does not show statistically significant effect on the pregnancy outcome. There was no statistically significant effect of lupus nephritis, antiphospholipid syndrome or mother's hypertension on the pregnancy outcome in patients with systemic lupus erythematosus.