OBJECTIVES: To examine whether there is an impact of age, pathohistological degree of malignancy, extent of surgical resection, preoperative clinical condition, adjuvant treatment, comorbidities and habits (arterial hypertension, weight gain, and smoking) onto the quality of life after surgical treatment of brain glioma. STUDY DESIGN: The research was organized as a cross-sectional study. PARTICIPANTS AND METHODS: The study included patients diagnosed with brain glioma in the period from 2016 to 2020 who were treated at the Clinics of Neurosurgery and the Department of Oncology of the Clinical Hospital Center Osijek. The patients' data were taken from the medical documentation stored at the Clinical Department of Pathology and the Department of Oncology of the University Hospital Center Osijek. Two questionnaires of the European Organization for Cancer Treatment were used as a research instrument: EORTC QLQ-C30, a basic questionnaire assessing the quality of life in patients with malignant tumors, and the EORTC QLQ-BN20, an additional questionnaire examining problems specific to the brain tumor. RESULTS: Among the examinees, cognitive functioning was evaluated as the best, and social and role functioning as the worst. The most common symptoms were leg weakness, motor dysfunction, fatigue and drowsiness, loss of appetite and difficulty communicating. Statistically, the quality of life was significantly associated with gender, degree of malignancy, pre-operative clinical condition, adjuvant treatment and comorbidities, more specifically arterial hypertension and weight gain. There was no significant correlation between the age and extent of surgical resection with the quality of life after surgical treatment of brain glioma. CONCLUSION: Various factors affect the quality of life after surgical treatment of brain glioma. Patients with a higher grade glioma, KPS values lower than or equal to 70, and those with comorbidities (arterial hypertension and increased body weight) have a significantly worse quality of life. The age and extent of surgical resection are factors that do not affect the quality of life.