OBJECTIVES: To evaluate the prognostic value of circulating calprotectin in the early prognosis of sepsis death. STUDY DESIGN: The study is design as case control study. PARTICIPANTS AND METHODS: The study included 108 participants divided into 3 groups. Participants with a confirmed diagnosis of sepsis were divided into two groups - 39 deceased and 39 survivors, the control group consisted of 30 healthy participants. Calprotectin concentration was determined from patients plasma, other inflammatory indicators were taken from the history of disease. Statistical tests examined the difference in calprotectin concentration between the 3 study groups, and also differences between groups of participants with fatal outcome and with survival outcome for the examined parameters (CRP, PCT, CircCPRO, IL-6 and leukocytes). The correlation test determined correlation between circulating calprotectin and other examined markers of inflammation. Research examined potential predictive variables (CRP, PCT, CircCPRO, IL-6, and leukocytes) for sepsis outcome. Research determined sensitivity and specificity of circulating calprotectin in differentiating participants with a confirmed diagnosis of sepsis in relation to the control group of healthy individuals, and the sensitivity and specificity of circulating calprotectin in differentiating participants who died in relation to surviving participants. The diagnostic method used in the study is chemiluminescent immunassay. RESULTS: Calprotectin has been shown to be a significant predictive marker in the assessment of sepsis outcomes, with a sensitivity of 87,2 % and a specificity of 64,1%. Calprotectin also showed diagnostic accuracy with a sensitivity of 96,15 % and a specificity of 93,33%. CONCLUSION: Circulating calprotectin has significant prognostic potential and can be used as a biomarker in assessing the fatal outcome of sepsis. It also showed diagnostic accuracy in distinguishing participants with a confirmed diagnosis of sepsis and healthy participants.