Title: Amniotic membrane transplantation in the treatment of anterior segment eye diseases Objectives: The objectives of this study were to evaluate the distribution of transplanted patients based on the surgical technique used, the indications for the procedure, and the need for reoperation during the period from 2013 to 2023, as well as to examine whether there are differences in outcomes depending on the surgical technique used. Study Design: A cross-sectional study with historical data Patients and Methods: The study included patients who underwent amniotic membrane transplantation at the Department of Ophthalmology, University Hospital Center Osijek, during the period from 2013 to 2023. The study utilized medical records that contain data on the indication for the hAM transplantation procedure, visual acuity before and after the procedure, any potential reoperation, demographic characteristics (age, gender), and the technique used for amniotic membrane transplantation. These data were statistically analyzed and compared. Results: The study was conducted on 69 patients with a median age of 77 years. The most frequent indication for amniotic membrane transplantation was bullous keratopathy in 52 patients (75.4%), followed by deep corneal ulcers in 7 patients (10.1%), and corneal perforation in 5 patients (7.2%) The majority of patients, 40 (58%), underwent a single-layer procedure. Reoperation was necessary in six patients (8.7%). No significant association was found between the type of procedure and the need for reoperation (Fisher's exact test, P = 0.24). The patients' visual acuity significantly improved after the procedure (Wilcoxon test, P < 0.001). Conclusion: Amniotic membrane transplantation has been shown to be an effective method for treating various corneal pathologies, although a small number of patients required reoperation. No significant association was found between the type of procedure and the frequency of reoperations.