The research goal: analyse the level of psychical wellbeing with medical students of the first and the final year; analyse the distribution of usage of individual stress reaction mechanisms (coping mechanisms); analyse the abundance of individual negative behaviours like unhealthy diets, irregular sleeping patterns, insufficient physical activities and usage of variety of stimulants - and to compare the analysis results between the students of the first and the final year and between genders. Research draft: cross-sectional research Examinees and methods: medical integrated pre- and postgraduate medical students of the first and the sixth (final) year participated in this research. Research was conducted on the Faculty of Medicine in Osijek. Information gathering method were anonymous questionnaires. Results: the results of 116 examinees were used. The results show that the first year medical students have more frequent body weight oscillations (28% examinees claim to gain body weight, and only 8% lose weight), they are more susceptible to consuming energy drinks during studying time (10%), undertake less physical activities (44%), but however practice healthier diet (20) and avoid taking sleeping tablets. However, the sixth year medical students practice more physical activities (54%), are more inclined to taking caffeine beverages (73%) and are more inclined to consumption of sweets and fast food during studying time (32%). Some results show more inclination towards consumption of alcohol and marihuana (9%) unlike the freshman students, who claim to consume none of the mentioned. Conclusion: first year medical student examinees are more often to attend lectures and learn on everyday basis, unlike the sixth year students. Sixth year students developed better problem solving skills, expressing emotions and development of self-confidence, when compared with the freshman students. Sixth year examinees are more relaxed and can better cope with problems, whereas the freshman students have somewhat worse results. However, the sixth year students developed some negative behavioural patterns like taking sleeping tablets and practice of whole night studying.