Objective: The aim of this study is to research and compare the findings of the quality control of platelet concentrates derived from buffy coat and those prepared by thrombocytapheresis. Materials and Methods: For the purpose of the study, quality control data for KT CELL SBL and KT POOL SBL were used in the period from May 1, 2015 to December 31, 2016. Criterias: volume of preparation, platelet count, number of remaining leukocytes, pH preparation, microbial purity were analyzed on the automatic hematological analyzer Mindray BC-3600, Adam rWBC automatic device and acid-status apparatus and in the BACT / ALERT microbiological laboratory. The results of the analysis are shown graphically and table-like, showing the absolute values and proportions for each individual platelet composition group. To compare the categorical data between the independent groups, the Hi squared test was used, and if necessary, the Fisher's exact test. The level of statistical significance was set at α = 0.05, and the analysis was performed by the statistical tool MedCalc (Inca 14.12.0, MedCalc Software bvba). Results: From the obtained results, a significant difference was found for the criterion "Total Platelet Content" where KT POOL SBL formulations had slightly more non-conforming findings compared to KT CELL SBL. All results meet the requirements and standards of quality control. Conclusion: The study concluded that both types of preparations meet the quality control requirements and standards prescribed by the following criteria: volume, platelet count, number of remaining leukocytes, pH of the product and microbiological purity of the preparations KT POOL SBL. The number of incompatible preparations is within the limits of the requirements of the quality control. The preparations of KT CELL SBL and KT POOL SBL have no significant differences in their properties and therefore is the use of both products justified, as well as their production procedures.