INTRODUCTION: Psychosocial factors are an important aspect of schizophrenia, both in terms of psychopathological vulnerability and in terms of their results with regard to patients’functional capacity. Treatment effectiveness is influenced by a number of psychosocial factors and their importance is also reflected in one’s quality of life. AIM OF THE RESEARCH: The aim of this research is to examine the extent to which psychosocial factors (sociodemographic variables, duration of illness, number of hospitalizations, type of therapy, cognitive functions, emotional competence, self-efficacy, locus of health control, coping strategies) are related to therapeutic effectiveness (remission) and outcome (quality of life). PARTICIPANTS AND METHODS: The research included 102 patients with ICD-10 and DSM-V diagnosis of schizophrenia, hospitalized at the Department of Psychiatry of the University Hospital Centre Osijek between June 2017 and June 2018. The patients were divided in two groups according to remission criteria: remitted (38.2 %) and non-remitted (61.8 %). The assessment of clinical factors was done by a psychiatrist, and assessment of psychosocial factors by a clinical psychologist. The battery of instruments used for assessment included the following: clinical and sociodemographic status questionnaire designed for research purposes, PANSS Positive and Negative Syndrome Scale, KNT-test for intelligence measuring, AVLT-test for verbal memory assessment and d2 test of attention. Emotional competence was estimated by the UEK-45 questionnaire, self-efficacy by the SOS questionnaire, coping strategies by the CISS questionnaire and the locus of health control by the ZLK-90 questionnaire. Quality of life was estimated bythe KVŽ-90 questionnaire. RESULTS: Remitted participants achieved higher scores in verbal memory and concentration. Significantly larger number of non-remitted participants have below average intelligence. Non-remitted participants used avoidance and distraction strategies more frequently, they had higher PANSS total scores and higher scores on the Negative Syndrome Scale. At discharge, all the PANSS-measured symptoms were significantly more pronounced in the non-remitted participants. Quality of life notably correlated with certain psychosocial factors in both groups of participants. In the group of remitted participants, the quality of life and its domains correlated positively with the ability to govern emotions, self-efficacy, being employed and financial independence, while they correlated negatively with the external locus of health control (influence of fate), PANSS total score and high score on the General Psychopathology Scale at discharge. In the group of non-remitted participants, the quality of life and its domains correlated with better ability to concentrate, total emotional competence and its domains, self-efficacy, task-oriented strategies, social diversion and marital status. Coping strategies (task-oriented coping, social diversion and distraction) are significant predictors of schizophrenia patients’ quality of life, but with the mediating effect of emotional competence. Factors that significantly contribute to discriminating between the two groups are the scores achieved on the PANSS Positive and Negative Scale at discharge, verbal memory and concentration, self-efficacy and avoidance-oriented coping. CONCLUSION: Therapeutic effectiveness and outcomes in patients with schizophrenia correlate with certain psychosocial factors. Complexity of relationship between those factors opens up an array of possibilities for further research and emphasizes the significance of multidisciplinarity in planning therapeutic approaches and methods.