Aims: This research has tried to answer to the questions related to the issues in the health information translation and presentation, how to assess and improve factors underlying the understanding of evidence-based medicine findings and finally how to assess knowledge in evidence-based medicine. Methods: The research on information presentation were randomized studies and focus groups performed on different populations which are included in healthcare system. In health numeracy research, and in the assessment of knowledge of evidence-based medicine as well, we used controlled before-and-after and cross sectional designs. Results: Infographics and blogshots were shown to be slightly better presentation types compared to plain language summary. Health numeracy levels were high in the population of medical students, and those were higher in clinical years compared to lower years. Through the new measure of knowledge in evidence-based medicine we demonstrated that the knowledge in evidence-based medicine field depends on the recently learned content and everyday practice. Conclusion: In the development of health messages one should take into account finantial possibilities of the project, if most presentation formats yield similar results, and health numeracy of the population which the content is being presented. Finally, in the assessment of knowledge in evidence-based medicine one sohuld take into account educational outcomes of the course, and measure them accordingly.