Objective: To evaluate the incidence of post-ERCP pancreatitis (PEP) among patients who were subjected to that procedure in KBC Split during the years 2020 and 2021, and to explore if there is a correlation with the usage of premedication (indomethacin or diclofenac suppository in combination with intravenous hydration). Our goals were also to determine the type and the incidence of other unwanted outcomes of the procedure, possible geographical differences in indications and complications of ERCP among patients from different counties and to compare our findings with those of other researchers. Subjects and methods: We observed the period between January 1st 2020 and December 31st 2021. For that period, we have found 841 subjects. Exclusion criteria were the inavailability of medical records and active acute pancreatitis at the time of the procedure. Data was collected from the archived medical histories and documents available in the hospital information system. Qualitative and quantitative data was compared using χ2 and Kruskal-Wallis tests. Results: During the observed period of time, 841 procedure was performed. Out of the total number of subjects, there were 400 (48%) women and 441 (52%) men. Median of age was 73 years (Q1-Q3: 63-81; min.-max.: 20-99). There were 18% of outside patients (people sent from institutions cooperating with KBC Split). There was no statistically significant difference between other institutions and KBC Split in terms of indications; however, there was a statistically significant difference in terms of incidence of PEP (p=0.007). Among the patients from KBC Split (N=686), 81 (11.8%) developed PEP, whereas among the patients from other institutions (N=155), the incidence was 5 (3.2%). The most common indications for performing ERCP were choledocolithiasis (54.4.%), proven or suspected pancreatic head tumor (11%) and obstructive jaundice of undetermined cause (9.7%). Premedication was administered to 323 (38%) patients. Complicatons didn't occur in 87% of the patients subjected to ERCP, keeping in mind that 128 procedures (15%; 95%CI 13-18%) were unsuccessful. PEP developed in 86 patients (10%; 95%CI 8-12%), among whom 35 (41%) were premedicated and 51 (59%) weren't. We haven't found a statistically significant correlation between outcome and premedication (p=0.089). Conclusions: The results from our research haven't confirmed a correlation between using premedication and the development of post-ERCP pancreatitis. ERCP went by without complications in over 80% of the cases. The recorded incidence of post-ERCP pancreatitis was 10%, which is higher compared to previous scientific reports and requires further research.