Objectives: Breast cancer is a major public health problem but by detecting breast cancer in a localized stage, it is curable in a large number of cases. The National breast cancer early detection program invites women to free mammography examinations every two years and the goal is to increase the frequency of breast cancer diagnosis. With this research, we will investigate the causes of poor response to mammography screening in University Hospital of Split. Patients and methods: A cross-sectional study was conducted with data taken in the period from March 6th, 2023. until March 24th, 2023. The study included women who were invited to a regular mammography examination by the National Breast Cancer Early Detection Program but did not respond to the examination. The research was conducted at the Department of Diagnostic and Interventional Radiology of University Hospital of Split. Results: Out of the 174 women who were included in the research, only 51.1% of the respondents received an invitation for a mammographic examination. Furthermore only 74.7% of them want to continue receiving calls. The main reason for non-arrival is the wrong address, 48.9%. The second biggest reason given by women was that they worked earlier in a different way, 16.7%. And as a third reason, we can mention two that are similar, 10.3% of them state that they were sick, and 9.2% that they were absent Conclusion: With regular mammography examination, we can greatly reduce the detection rate of breast cancer that has metastasized and mortality. It is necessary to advertise more and inform women about breast cancer, symptoms, risk groups and risk factors. With better organization and advertising through various media, it is possible to reach the target group of women who are poorly informed. It is also necessary to raise women's awareness of the frequency of breast cancer and how invasive it is.