| Sažetak | Cilj: Cilj istraživanja je procijeniti kvalitetu sažetaka randomiziranih kontroliranih kliničkih
istraživanja u kojima se ispitivala učinkovitost korištenja topikalnog niacinamida.
Materijali i metode: Sažetci istraživanja pretraživani putem PubMed tražilice u MEDLINE bazi
podataka uz ključne riječi ,,niacinamide'' i ,,skin'' te ,,niacinamide'' i ,,topical'' uz filter
,,randomized controlled trial''. Sažetci su analizirani s obzirom na prisutnost stavki CONSORTA liste za sažetke. Za analizu podataka i interpretaciju rezultata korišten je program MedCalc.
Rezultati: Pretraživanjem baze MEDLINE pronađeno je 129 sažetaka, od kojih su u daljnju
analizu uključena 23 sažetka. Vrijednost medijana za zbroj svih stavki CONSORT liste iznosi 7,
a interkvartilni raspon 5,25 do 8. Analizom strukturiranih i nestrukturiranih sažetaka, uočena je
usporedna prisutnost CONSORT stavki od kojih se samo stavka ,,zaključak'' pokazala statistički
značajnom s p-vrijednošću od 0,006. Navedena stavka zastupljena je u svih 16 strukturiranih
sažetaka, dok njezina prisutnost u nestrukturiranim sažetcima iznosi 57,14% (N=4). Ovakva pvrijednost ukazuje na razlike u sastavljanju strukturiranih i nestrukturiranih sažetaka koje mogu
utjecati na razumijevanje i interpretaciju rezultata. Najviše zastupljene stavke uključuju
intervencije, cilj, ishod i zaključak, dok najnižu pojavnost imaju dizajn istraživanja, sudionici,
randomizacija, štetni učinci, registracija i izvor financiranja.
Zaključak: Nedostatak visokokvalitetnih sažetaka istraživanja ograničava sposobnost donošenja
odluka i pristup pouzdanim informacijama o topikalnoj primjeni niacinamida. Sažetci niske do
umjerene kvalitete mogu biti nedovoljno jasni, potpuni i prezicni te otežati razumijevanje
informacija stoga je ključno poticati pridržavanje smjernica CONSORT-a. |
| Sažetak (engleski) | Objectives: The aim of this research is to assess the quality of abstracts of randomized controlled
clinical trials investigating the effectiveness of topical niacinamide.
Materials and methods: Abstracts of relevant studies were searched using the PubMed search
engine in the MEDLINE database with the keywords ,,niacinamide" and ,,skin," as well as
,,niacinamide" and ,,topical," with the filter ,,randomized controlled trial." Abstracts were
analyzed for the presence of items from the CONSORT-A checklist for abstracts. Data analysis
and interpretation of results were conducted using the MedCalc software.
Results: A total of 129 abstracts were found through the MEDLINE database search, of which 23
abstracts were included in the further analysis. The median sum score for all CONSORT
checklist items was 7, with an interquartile range of 5,25 to 8. Analysis of structured and
unstructured abstracts revealed a comparable presence of CONSORT items, with only the
,,conclusion" item showing statistical significance. This item was reported in all 16 structured
abstracts, while its presence in unstructured abstracts was 57,14% (N=4). Such a p-value
indicates differences in the composition of structured and unstructured abstracts that may
influence the understanding and interpretation of the results. The most commonly reported items
include interventions, objectives, outcomes, and conclusions, while the lowest occurrence is
observed for study design, participants, randomization, adverse effects, registration, and funding
source.
Conclusion: The lack of high-quality research abstracts limits the ability to make informed
decisions and access reliable information on the topical application of niacinamide. Abstracts of
low to moderate quality may be insufficiently clear, complete, and precise, thus complicating
information comprehension. Therefore, it is crucial to encourage adherence to CONSORT
guidelines. |
