In the very beginning, the COVID-19 pandemic was considered an isolated case, certainly not a threat to the entire world. With a rapid spread of the virus and an increased number of deaths came a global lockdown, which had the most effect on tourism, and with it all the subjects that do business within it. Tourist agencies found themselves in a tricky position that was brought by the global measures against the pandemic, which, therefore, decreased tourist activity to a minimum. A 46% decrease in total sales shows the scope of the negative effect of the COVID-19 pandemic on the travel agencies business globally in 2020., as well as a decrease of the retail sales price of all business activities. Among all tourism regions of the world, Western Europe experienced the biggest decrease of total sales of 58%. An increase in the share of online business activities of travel agencies should be considered a rare positive impact of the pandemic on their business, that is an opportunity to improve the quality of communication with and representation to the subjects on the tourism demand side. On a global level, in the year of 2020. tourism intermediaries generated the largest revenue from the sale of travel packages, and, from the world's tourist regions, the Asia-Pacific region achieved the best results. In the year of the pandemic, among the global brands in the field of tourism mediation, the first place in terms of company value was taken by the Trip.com group, followed by long-term rivals Expedia in the second place and Booking in the third place. The pandemic has left its mark on all subjects that are part of tourism in a direct or indirect way. Changes in demand, funding difficulties and rising costs have forced travel agencies to make radical business moves such as closing offices temporarily or permanently, cutting costs and even laying off staff. Some were forced by the difficult business situation to consider moving to other sectors, and this idea was pushed by inadequate support from the institutions from which it was expected.