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The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy
Medicina, 58 (2022), 2; 252-266. https://doi.org/10.3390/medicina58020252
Mikolačević, Ivana; Domislović, Viktor; Krznarić- Zrnić, Irena; Krznarić, Zeljko; Virović-Jukić, Lucija; Stojsavljević, Sanja; Grgurević, Ivica; Milić, Sandra; Vukoja, Ivan; Puž, Petra; Aralica, Merica; Hauser, Goran

Institucijski repozitorij: Repozitorij OŽB Požega

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Mikolačević, I., Domislović, V., Krznarić Zrnić, I., Krznarić, Z., Virović Jukić, L., Stojsavljević, S. ... Hauser, G. (2022). The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy. Medicina, 58. (2), 252-266. doi: 10.3390/medicina58020252

Mikolačević, Ivana, et al. "The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy." Medicina, vol. 58, br. 2, 2022, str. 252-266. https://doi.org/10.3390/medicina58020252

Mikolačević, Ivana, Viktor Domislović, Irena Krznarić Zrnić, Zeljko Krznarić, Lucija Virović Jukić, Sanja Stojsavljević, Ivica Grgurević, et al. "The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy." Medicina 58, br. 2 (2022): 252-266. https://doi.org/10.3390/medicina58020252

Mikolačević, I., et al. (2022) 'The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy', Medicina, 58(2), str. 252-266. doi: 10.3390/medicina58020252

Mikolačević I, Domislović V, Krznarić Zrnić I, Krznarić Z, Virović Jukić L, Stojsavljević S, i sur.. The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy. Medicina [Internet]. 2022. [pristupljeno 05.11.2024.];58(2):252-266. doi: 10.3390/medicina58020252

I. Mikolačević, et al., "The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy", Medicina, vol. 58, br. 2, str. 252-266, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:267:004975. [Citirano: 05.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:267:004975
Podaci o radu
Naslov (engleski)The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy
AutorIvana Mikolačević
AutorViktor Domislović
AutorIrena Krznarić- Zrnić
AutorZeljko Krznarić
MBZ: 75865
AutorLucija Virović-Jukić
AutorSanja Stojsavljević
AutorIvica Grgurević
AutorSandra Milić
AutorIvan Vukoja
AutorPetra Puž
AutorMerica Aralica
AutorGoran Hauser
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background and Objective: This study was conducted to evaluate the diagnostic performance of various biomarkers for steatosis, fibrosis, and inflammation in comparison to a liver biopsy (LB) in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: This was a cross- sectional study that included 135 patients with biopsy-proven NAFLD. Fatty liver index (FLI), hepatic steatosis index (HSI), cell death markers (CK-18 M30 and CK-18 M65), FIB-4 index, NAFLD fibrosis score (NFS), BARD, and AST to platelet ratio index (APRI) were calculated and analysed. Results: FLI, HSI scores, and the cell death biomarkers showed poor diagnostic accuracy for steatosis detection and quantification, with an area under the curve (AUC) of <0.70. The cell death biomarkers likewise did not perform well for the detection of nonalcoholic steatohepatitis (NASH) (AUC < 0.7). As for the fibrosis staging, only APRI and the cell death biomarkers had moderate accuracy (AUC > 0.7) for advanced fibrosis, whereas FIB-4, BARD, and NFS scores demonstrated poor performance (AUC < 0.70). However, a combination of FIB-4 and NFS with the cell death biomarkers had moderate accuracy for advanced (≥F3) fibrosis detection, with an AUC of >0.70. Conclusions: In this first study on Croatian patients with NAFLD, serum biomarkers demonstrated poor diagnostic performance for the noninvasive diagnosis of liver steatosis and NASH. APRI and the cell death biomarkers had only moderate accuracy for diagnosing advanced fibrosis, as did the combination of FIB-4 and NFS with the cell death biomarkers. Further studies regarding serum biomarkers for all NAFLD stages are needed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicina
Brojčani podacivol. 58, br. 2, str. 252-266
p-ISSN1648-9144
e-ISSN1010-660X
DOIhttps://doi.org/10.3390/medicina58020252
URN:NBNurn:nbn:hr:267:004975
Datum objave publikacije2022
URL dokumentahttps://www.mdpi.com/1648-9144/58/2/252/htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-04 07:09:54