The aim of this study was to investigate the number of children born with cleft lip and/or palate in a five-year period from 2018 to 2022 in Split-Dalmatia County. The results included birth weight, birth length, sex of the child, age of the mother, order of pregnancy, Apgar score at the 1 st and 5th minute, type of cleft, extent of cleft and additional anomalies. Seventeen children were treated at the Department of Neonatology, Clinic for Gynecology and Obstetrics, University Hospital Split. The medical documentation of children with clefts was used from the archives of the Clinic for Gynecology and Obstetrics Split. The results of the research indicate that of the 21 273 children who were born from 2018 to 2022 in Split, 0.07% were born with a cleft lip and/or palate. The frequency of cleft lip and/or palate was higher in male newborns than in female. The most common associated anomaly was patent foramen ovale, while the rarest anomaly was anal atresia with a perianal fistula. Other anomalies in children with clefts included Pierre Robin syndrome and atrial septal defect.