The aim of this study was to demonstrate and explain the role and importance of a bachelor’s trained nurse in HLA antigens monitoring procedure of patients that are on a transplant waiting list; in addition to its effect on transplantation and subsequent life of patients after the procedure. The HLA system is a very important system in our body. It recognizes foreign cells as dangerous and treats them as such. Its role is very important because it protects us from foreign bodies and does not allow them to remain in our system. However, when it comes to transplantation its role does not necessarily work in favor of the organ receiver. Therefore, it is necessary to conduct various tests and monitor how HLA responds to foreign cells in order to determine if it is even compatible and if it can accept them as their own. If it cannot, there is a great possibility that the body will reject the transplant. The role of a bachelor’s trained nurse is significant and it starts with the conversation with the patient of who is waiting for the transplant. When it comes to monitoring sensibility, the nurse also plays an important role. Starting from taking samples for different tests, checking the names on the test tubes, tracking results, etc. At receiving the organ, the nurse controls amount of ice, organ position, box where the organ is, declaration on the box and all accompanying documentation. Then when the time for the transplant arrives upon matching a suitable organ, the nurse educates the patient about the scan plan, informs him of all the information related to the transplant, takes blood samples for laboratory tests, she is physical and psychological support both for the patient and his family, educates them about appropriate lifestyle and goes in home visit.