Ginkgo biloba is an herb that is, due to its wide range of medicinal and therapeutic properties, used as an alternative medicine to treat numerous indications. It is considered that the foundation of its therapeutic effect is high antioxidant activity of its compounds. Aging and environmental and dietary xenobiotics can cause a buildup of free radicals that lead to oxidative stress, damage and cell death. Kidneys are exposed to a number of xenobiotics that can cause oxidative damage. The aim of this research was to investigate the possible nephroprotective effect of three Ginkgo biloba supplements in Y59 rats after treatment, which lasted for 30 days. The results showed statistically significant (ANOVA, p <0.05) increase in the activity of antioxidant enzymes SOD (superoxide dismutase) and CAT (catalase) and the concentration of GSH (reduced glutathione) in kidneys of rats treated with Ginkgo biloba and Ginkgo ALERT. It indicates their protective antioxidant effect. These supplements significantly decreased MDA levels (malondialdehyde). The opposite effect had supplement Vulkan, herbal medicine for impotence, which statistically significant (ANOVA, p <0.05) decreased activities of antioxidant enzymes and increased MDA concentrations indicating oxidative stress.