The cruise industry is one of the most dynamic and fastest growing segments of the tourism industry and maritime passenger traffic. The growth rate of cruises on a global level was constantly increasing until the COVID-19 pandemic hit the whole world, and especially the cruise industry. Currently, the cruise industry is returning to the level of passenger movement before the pandemic, both globally and on the Mediterranean and Adriatic levels. According to the number of passengers and the number of cruise ship calls, the Adriatic is, in comparison with other regions of the Mediterranean (Western and Eastern Mediterranean), currently the fastest growing region of cruises in the Mediterranean. Therefore, the basic problem of this research is the analysis of the state and perspective of passenger flows on cruise trips along the Adriatic. In doing so, the main goals and structure of the paper are focused on the analysis of: the intensity and dynamics of passenger flows on cruise trips, the leading ports and leading cruise companies, and the sustainability and future development of the Adriatic as a cruise region, considering the state of passenger flows on cruise trips in the global and regional sense of the Mediterranean.