The drugs we use on the skin with the active substance also contain auxiliary substances that make 90% of the dermal drug content. The most commonly used excipients in the currently approved dermal drugs in the Republic of Croatia are: propylene glycol, lanolin, cetyl alcohol, benzalkonium chloride, chlorocresol, parabens, isopropyl myristate and stearyl alkanoates. Lanolin is one of the oldest emulsifiers used to make dermocosmetic products. Due to the penetration ability in deep layers of epidermis it is used in dry skin care products. The appearance of allergic contact dermatitis is more common in patients who already have atopic dermatitis. Isopropyl myristate possesses emollient properties, and due to good penetration through the skin it is considered to potentiate the potential irritant effect of other substances as it improves their penetration through the skin. In 2018, propylene glycol was declared as an allergic due to more often allergic reactions. There was an increased incidence of contact dermatitis after the use of dermocosmetic products for skin with atopic dermatitis. Stearil heptanoate and due to its similar structure other stearyl alkanoates are considered safe for use in dermocosmetic products. Cetyl alcohol is considered to be safe for use and dermatitis, that may occur after using cetyl alcohol creams, can cause some inpurity in the alcohol itself, which is not detected by gas chromatography. Benzalkonium chloride has a limited concentration in the preparations at 0.1%. It is one of the most common allergens even though due to the hydrophilic structure it is difficult to penetrate through the skin. Chlorocresol is used as a preservative and if used within permitted concentrations is not a common cause of allergic contact dermatitis Parabens have the role of preservatives, weakens sensitizers and irritants when applied to normal skin. There are frequent cases of allergic contact dermatitis, and their potentially damaging effect on the endocrine system is examined.