Objectives The aim of this paper is a systematic review of the five widely used herbs from traditional Indian medicine. The herbs selected should have relevant clinical studies having in mind the actions and safety of their herbal preparations. The selected herbs are Asparagus racemosus (Sanskrit, shatavari), Ocimum tenuiflorum (Sanskrit, tulsi), Phyllanthus emblica (Sanskrit, amalaki), Tinospora cordifolia (Sanskrit, guduchi) and Withania somnifera (Sanskrit, ashwagandha). Materials/Patients and Methods For the search is used electronic database PubMed with the keywords that include Latin, English, and Sanskrit plant names and known synonym of the selected spices. Scientific papers have been studied based on their summary and are limited to clinical studies, published in English, of the selected plant species. Papers matching the selected criteria were to be included regardless of the date of their publication. Results This paper selected and researched a total of 76 clinical studies of the selected adaptogenic plants within traditional Indian medicine. The work includes 6 clinical studies for the species Asparagus racemosus, 15 studies for Ocimum tenuiflorum, 27 studies for Phyllanthus emblica, 10 studies for Tinospora cordifolia and 18 studies for species Withania somnifera. The selected plant species showed significant efficacy and tolerance in the published and researched clinical studies analysed in this paper. The herbal species A. racemosus is effective in treating digestion problems. Spices O. tenuiflorum demonstrated significant antimicrobial activity. The plant P. emblica has also been shown to have antimicrobial activity but has also proven effective in treating many modern diseases, particularly diabetes type II, and as an anti-inflammatory agent. The studies showed that spices T. cordifolia modulates lipid metabolism, reduce blood glucose levels, enhance immune processes in the body and acts as an immunomodulator. Perhaps the most popular plant species in the West, W. somnifera or ashwagandha, has shown positive effects on the neurological diseases, improving the cognitive function of the organism. Studies have also shown that it reduces oxidative stress, which may be one of the reasons for W. somnifera’s effectiveness in normalizing thyroid function and reducing infertility in women and men. Conclusion A review of 76 clinical studies included in this paper revealed that the selected plant species showed the efficiency and a positive effect on the organism. They support defence mechanisms, increase resistance to stress and improve physical, and mental health. This partly justifies their classification as adaptogens, however, additional welldesigned clinical studies with standardised herbal preparations are needed to thoroughly examine their efficacy and safety.