prikaz prve stranice dokumenta Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells
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Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells
Farmaceutski glasnik, 73 (2017), 2; 85-97. urn:nbn:hr:163:659506
Petlevski, Roberta; Knežević, T.; Ris, M.; Filipašić, A.

Institucijski repozitorij: Repozitorij Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu

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Petlevski, R., Knežević, T., Ris, M. i Filipašić, A. (2017). Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells. Farmaceutski glasnik, 73. (2), 85-97. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:163:659506

Petlevski, Roberta, et al. "Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells." Farmaceutski glasnik, vol. 73, br. 2, 2017, str. 85-97. https://urn.nsk.hr/urn:nbn:hr:163:659506

Petlevski, Roberta, T. Knežević, M. Ris i A. Filipašić. "Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells." Farmaceutski glasnik 73, br. 2 (2017): 85-97. https://urn.nsk.hr/urn:nbn:hr:163:659506

Petlevski, R., et al. (2017) 'Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells', Farmaceutski glasnik, 73(2), str. 85-97. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:163:659506 (Datum pristupa: 06.11.2024.)

Petlevski R, Knežević T, Ris M, Filipašić A. Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells. Farmaceutski glasnik [Internet]. 2017. [pristupljeno 06.11.2024.];73(2):85-97. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:659506

R. Petlevski, T. Knežević, M. Ris i A. Filipašić, "Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells", Farmaceutski glasnik, vol. 73, br. 2, str. 85-97, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:163:659506. [Citirano: 06.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:163:659506
Podaci o radu
Naslov (engleski)Protective effect of flavanone - naringenin on high glucose-induced hepatotoxicity to Hep G2 cells
AutorRoberta Petlevski
AutorT. Knežević
AutorM. Ris
AutorA. Filipašić
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
(Zavod za medicinsku biokemiju i hematologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Medicinska biokemija
Sažetak (engleski)
Naringenin is a flavanone, a type of flavonoid that is considered to have a bioactive effect on human health as antioxidant, free-radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. This study was initiated to determine in which of the examined concentrations at the range 1-1000 μM of the naringenin has the protective effect on high glucose-induced toxicity in Hep G2 cells. The treatment of Hep G2 cells with 30 mM glucose significantly increased the levels of hepatic functional markers such as AST, ALT, LDH and GGT, decreased cell viability (MTT test), and decreased the activity ofhepatic antioxidative enzyme: glutathione peroxidase (GPx), when compared with norma! glucose level (p<0.05). We showed, that naringenin at concentration 1 to 100 μmol/L had hepatoprotective effect on Hep G2 cells under hyperglycemic condition, but at a concentration of 1000 μmol/L this effect is lost and naringenin showed toxic effect.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - domaća recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFarmaceutski glasnik
Brojčani podacivol. 73, br. 2, str. 85-97
p-ISSN0014-8202
URN:NBNurn:nbn:hr:163:659506
Datum objave publikacije2017
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-06-17 07:30:35