Colorectal cancer surgery, as well as all severe surgical procedures, lead to strong acute phase response and systemic inflammatory response syndrome (SIRS). The extent and the cause of SIRS are monitored with acute phase proteins that point to the cause and course of inflammatory process. The course and the individual response to acute inflammation are not completely understood. In early postoperative phase there is also an increasing importance in monitoring glycosylation changes, where large individual differences have been identified in acute systemic inflammation response. The aim of this study was to test the effect of radical colon resection on SIRS development by monitoring soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-6 (IL-6), procalcitonin (PCT) and C-reactive protein (CRP), as well as the changes in N-glycosylation profiles of total serum proteins and immunoglobulin G (IgG) in defined points of measurement that would define interdependence of acute inflammatory process and SIRS development with specific glycome and acute phase proteins changes. This study included 28 participants (19 men and 9 women) with a median age of 71 years (44-85) and with colorectal cancer diagnosis that underwent radical colon resection. Blood samples were collected in 4 measurement points: 24 hours before the surgery (T0), 24 hours after the surgery (T1), 48 hours after the surgery (T2) and 7 days after the surgery in order to define acute response to surgical stress, as well as to define the decrease of inflammations or notice the extended reaction to surgical stress. The results showed statistically significant differences of sTREM-1, CRP, IL-6 and PCT, as well as changes in N-glycan profiles of total serum proteins and IgG before the surgery and during 7 days of postoperative recovery. Significant correlations for IL-6, as well as some N-glycan structures of total serum proteins and IgG, were discovered with the duration of the surgery. Correlation and linear regression analysis revealed weak, moderate and very good correlations between CRP, IL-6, PCT and N-glycan profiles of total serum proteins and IgG. The strongest discovered correlation was the very good correlation of CRP with tetragalactosilated and syalinisated structure with antennary fucose. STREM-1 did not reveal any significant correlation with any other tested parameter. This study showed that radical colorectal cancer surgery does not necessarily lead to SIRS and the course and dynamics of inflammation as the response to surgical stress can be followed by the rise of the acute phase proteins. Changes of sTREM-1 concentrations can indicate that there is no SIRS development. This study also clarified that glycan profiles show very distinct change patterns that can be related to the acute phase proteins concentrations changes. Further research of the glycan profiles could open up the possibility of using the acquired data for individual monitoring of the early inflammatory response.