Pyrrolizidine alkaloids are compounds that naturally occur in some herbal species (mostly species of plant families Boraginaceae, Compositae/Asteraceae, Leguminosae/Fabaceae, Apocynaceae, Ranunculaceae, Scrophulariaceae) and they are products of secondary metabolism that plants have developed as defense mechanism against insect herbivores. The acute toxicity, genotoxicity and carcinogenic potential for humans caused by pyrrolizidine alkaloids have been known for a very long time and usually liver is the most affected by its toxic effects. Recently, it has been shown that a lot of plants that naturally do not contain pyrrolizidine alkaloids are starting to show otherwise. Certain content of pyrrolizidine alkaloids has been found in plants due to the same habitat, contamination or crossbreeding of species. By this appearance, rate of possible exposure to pyrrolizidine alkaloids significantly increases and it is spread to more various sources what presents potential health hazard, especially in regular consumers. In order to restrict pyrrolizidine alkaloid exposure, The European Commission has brought the decision to additionally limit content of pyrrolizidine alkaloids that is allowed in products like tea, herbal infusions, herbal supplements, pollen based products and spices which will be implemented on 1. July 2022. Even though we know a lot about pyrrolizidine alkaloids, regularly we come to the new insights. It is important to emphasize the fact that knowledge is power which allows us to implement measures due to the new insights to ensure safety and preserve health of population in which significant role has the pharmacist.