The aim of this thesis is to describe the pharmaceutical-technological forms and properties of vehicles which are used for making liquid and semi-solid dermal products. This thesis provides a detailed insight into the essential aspects of the bases for dermal application: from the ingredients used for their production to how to achieve desired biopharmaceutical properties of certain dermal base. Common vehicles for liquid and semi-solid dermal products are complex mixtures consisting of divers ingredients which makes it possible to optimize both the cosmetic features and to adjust a vehicle to the properties of an incorporated drug and site of application. Liquid dermal preparations are made in form of solutions, emulsions, suspensions or in form of modern dispersion such as a suspension of lipid vesicles (liposomes) or the lipid particles (solid lipid nanoparticles and nanostructured lipid carriers), nanoemulsions, microemulsions and multiple emulsions. Semi-solid dermal preparations usually comes in the form of ointments, creams, gels, pastes and foams. Ointments are non-aqueous single-phase basis with occlusive effect on the skin, creams are multi-phase preparations and can be divided into lipophilic, hydrophilic and amphiphilic. Gels can be single-phase or multi-phase dispersions, depending on the liquid phase they are divided into hydrogels, lipogels and amphiphilic gels. Pharmaceutical foams are preparations consisting of a large amount of gas dispersed in a liquid phase. From biopharmaceutical properties of liquid and semi-solid bases particularly important are effects on the regeneration of damaged skin - emollient and moisturizing effect and effects on dermal bioavailability of active substances.