Mental disorders are the leading global cause of mortality and morbidity. Pharmacological therapy represents the basis for the treatment of mental disorders and medication adherence is extremely important due to long-term treatment and serious consequences if the treatment is stopped prematurely. Intentional and unintentional non-adherence to antipsychotics is the main problem in the treatment of schizophrenia, which occurs due to the serious side effects of antipsychotics and because the patient is unaware of the illness. The first approved digital medication Abilify MyCite contains the antipsychotic aripiprazole as the active substance. lt represents the digital medicine system which contains a tablet with an ingestible sensor and active substance, a wearable patch, an application on a smartphone and a web portal. It works on the principle of transmitting the digital signal from the sensor to the wearable patch when the sensor comes into contact with gastric fluid. Data on drug ingestion, as well as other data on health and life habits, are stored on the web portal and become available to the doctor and other individuals, to whom the patient grants access. Another digital system in research is the ID-Cap system, with a sensor built in the capsule. lt works on the principle of transmitting a low-intensity radio signal to a reading device when the capsule comes into contact with gastric fluid. AiCure is a visual recognition system that records video and uses facial image analysis to verify that the patient has taken the prescribed medication. Digital medicine systems have been developed to improve adherence, thereby providing better therapy outcomes and reduced healthcare costs. However, there is no clinical evidence confirming that digital medications can consistently monitor medication ingestion in real-time or improve adherence. Furthermore, digital medications are accompanied by several ethical issues such as the negative impact on patient autonomy and privacy, the subjective feeling of coercion and control, the disturbed trust in the relationship between doctor and patient and the impact of pharmaceutical companies on the doctor. Further clinical research should be conducted with an emphasis on assessing the adherence and quality of life of patients taking digital medications. Also, doctors and patients should be educated about digital medications.