The role of nutrition in the prevention and treatment of numerous chronic indistinct diseases is increasingly being recognized as key to maintaining health, i.e. achieving optimal treatment outcomes. In this context, in addition to classical diet therapy, targeted vitamin and mineral supplementation is increasingly used, and in diseases with severe malnutrition, enteral formulas with an optimized nutritional composition. In addition to the balanced composition of essential macroand micronutrients, the new generation of enteral formulations very often contain non-essential components with proven biological effects, most often from groups of compounds with antioxidant effects. This paper investigated the effect of modifying the standard enteral formulation with the addition of functional components with regard to the content of polyphenols and other compounds with antioxidant activity. The total content of polyphenols was determined by the Folin-Ciocalteu method in defatted samples, after removing interfering proteins with the Carez reagent. The antioxidant potential was determined spectrophotometrically in the same samples, using the TEAC method. The obtained results showed that the addition of resveratrol to the formulation, as well as the replacement of part of the raw materials with whole grains, significantly increases the antioxidant activity of the samples and that polyphenols can be considered the main carriers of the antioxidant activity of the analyzed products. It was found that by storing the analyzed products at room temperature, the total antioxidant potential decreases slightly, but statistically significantly in samples enriched with olive-polyphenols and resveratrol. The obtained results will contribute to the understanding of current opportunities and limitations in the development of innovative formulations for enteral administration.