Objectives The aim of this reasrch is to provide an insight into the current key considerations of critical process parameters, to present the tools of process analytics to monitor the production process in real time and to ensure the critical attributes of the quality of the finished drug product, and thus to be a useful tool for further literature studies and the application of process analytical technologies in the production process. Most importantly, the work will raise awareness of the importance of continuous control of the production process for the manufacture of effective, safe and high quality medicinal products. Materials and Methods The research in the context of the technical paper is of a theoretical nature. By searching the relevant technical and scientific literature, regulatory guidelines, laws and regulations, data was collected on the control requirements for the production process of solid pharmaceutical forms. The backbone of the regulatory requirements is formed by the Good Manufacturing Practise (GMP) guidelines, national legislation, the Medicinal Products Act and associated regulations, the European Pharmacopoeia and the ICH guidelines (ICH stands for International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use). Bibliographic databases such as PubMed, Science Direct, ResearchGate, National Library of Medicine, Scopus, Web of Science were used to collect data on critical process parameters, critical quality attributes, product control strategies, process analytical technology (PAT) and its application in pharmaceutical production, production process control, NIR spectrometry, Raman spectrometry, continuous pharmaceutical production of tablets. Results The results are presented on the basis of the regulatory requirements for validation of the production process, continuous production and the application of PAT tools in pharmaceutical production of solid forms. The regulatory aspect shows the requirements of good manufacturing practise for access to process validation and continuous process verification. It also shows the requirements for continuous pharmaceutical production, ensuring the quality of the final product, monitoring and control of the production process. The most common critical process parameters and their impact on critical quality characteristics in the production of solid pharmaceutical forms are presented. The product control strategy and the application of PAT tools and the types of PAT tools that can be used in the production of tablets and film-coated tablets are described, as well as the regulation of the production process using real-time data. Conclusion To achieve high quality of the finished drug product, it is crucial to analyse the critical properties of the material and define the critical quality characteristics and process parameters in the development phase. Regulatory guidelines promote a scientific approach to development of pharmaceutical product using quality by design approach (QbD). Process validation or continuous process verification (CPV) is necessary before a drug is commercialised. A hybrid approach to validation combines traditional and continuous approaches. The use of advanced tools such as PAT, including in-line and on-line technologies, supports real-time quality monitoring. Continuous pharmaceutical production is considered the optimal choice for highly hazardous drugs but requires specialised equipment. An appropriate process monitoring strategy and the further development of technology, including artificial intelligence, are key factors on the road to Pharma 4.0. based on QbD.