Stable angina pectoris represents the most common clinical manifestation of ischemic heart disease, and is associated with impaired quality of life and increased risk of adverse cardiovascular events. It is important to recognize its symptoms and start treatment, which has two main goals. The first of them is the prevention and reduction of anginal symptoms and the improvement of quality of life, while the second goal is the prevention of serious cardiovascular events. The pathophysiological basis is the presence of obstructive coronary artery disease, that is, the presence of atherosclerotic plaques in the epicardial coronary arteries, which causes an imbalance between the heart's need for oxygen and the heart's oxygen supply. Pharmacological therapy of stable angina pectoris includes use of anti-ischemic drugs which try to restore balance between the heart's oxygen supply and the heart's need for oxygen, and drugs that prevent cardiovascular events. Among anti-ischemic drugs, first- and second-line drugs are distinguished, whereby β-blockers, calcium channel blockers and short-acting nitrates are included in the first line. In addition to long-acting nitrates, second-line drugs include nicorandil, ranolazine, trimetazidine, and ivabradine. Second-line drugs are used in case of contraindications for first-line drugs, in case of their intolerance or if good control of symptoms cannot be achieved with the first-line drug. It is important to point out that there are no comparisons between the first- and second-line drugs that would show the superiority of one group over the other in terms of effectiveness. Among the drugs that prevent cardiovascular events, antiplatelet drugs (acetylsalicylic acid, P2Y12 antagonists), statins and ACE inhibitors are important. Myocardial revascularization may be considered in patients who have prognostically significant lesions or symptoms despite optimal pharmacology therapy, where percutaneous coronary intervention, coronary artery bypass grafting or both can be performed.