Aim: The aim of this paper is to point out the particularities of the use of antipsychotics in children and adolescents and to emphasize the fact that children are not "small adults" but a population with a completely different level of neurodevelopment and different pharmacokinetic and pharmacodynamic properties that change significantly from infancy to middle and late adolescence. The paper presents an overview of antipsychotics approved for use in children and adolescents in the Republic of Croatia, along with related relevant scientific research. The study will also look at the importance of the role that pharmacists, as the most accessible healthcare professionals, can play when administering antipsychotics in the aforementioned population. Subjects and method: For this purpose, a systematic and retrospective review of scientific and professional literature was made, currently valid therapeutic guidelines, publications of professional associations and institutions, the drug database of the Agency for Medicines and Medical Products and other available sources were searched. Results: This paper provides an overview of antipsychotic drugs approved for use in children and adolescents in the Republic of Croatia. The specifics related to the use of certain drugs in children and adolescents and the associated relevant scientific research with each drug are highlighted. The importance of involving clinical pharmacists in order to improve adherence was emphasized. Conclusion: Children and adolescents constitute a special and sensitive group in the total population, primarily due to different pharmacodynamic and pharmacokinetic properties compared to adults. Accordingly, there is a small number of relevant randomized controlled clinical trials that are essential for the safety and effectiveness of the use of a particular drug in this population. We must not forget the important role of the clinical pharmacist, who with his professional competences can be of great help in providing information about the drug (dosage, side effects, interactions) to the parents, who ultimately approve the administration of the drug to the child with their consent. It is necessary and necessary to constantly train clinical pharmacists so that, together with the doctor, they form a strong and efficient team necessary for the numerous challenges that the profession gives them every day.