Liposomal gels (CL-CHG, PGL-CHG, CATL-CHG) were prepared by incorporating different types of AZT-liposomes into CHG at three different concentrations (10, 20, 30%, w/w). The incorporated liposomes had an average diameter ˂130 nm (CL, PGL) or 330 nm (CATL). The zeta potential of CL and PGL liposomes was strongly negative (-43 mV, -48 mV), while CATL exhibited strongly positive zeta potential (+59 mV). The viscosity curves obtained for the liposomal gels indicate that the phospholipid composition/surface charge of the liposomes, has an impact on the viscosity of the formulation, which is more pronounced at lower liposome concentrations in the formulation. Specifically, negatively charged CL and PGL liposomes at 10% or 20% cause an increase in viscosity compared to the original CHG, while for positively charged CATL at 10% and 20%, an opposite effect (viscosity decrease) was observed. At the highest liposome concentration in the gel (30 %), the viscosity of the formulation decreases regardless of the surface charge of the liposomes, which is likely the result of a significant reduction in the chitosan concentration in the gel due to dilution by the added liquid phase. During oscillatory amplitude tests, the original CHG and all liposomal gels show a wide LVR with a storage modulus (G') greater than the loss modulus (G''), which represents viscoelastic behavior characteristic of gels and confirms that the addition of liposomes to CHG at a concentration ≤ 30% (w/w) does not compromise the gel structure. The preserved gel structure can ensure prolonged retention at the site of application and extended drug release. Moreover, samples with a broad LVR region can also be considered well-dispersed and stable.