Hospital discharge is a critical point in patient health care. Changes in the therapeutic regimen during hospitalization are common and often accompanied by the introduction of new drugs. The patient's lack of understanding of changes in the therapeutic regimen can lead to poor adherence, ineffectiveness and side effects of medications, and rehospitalization. Pharmacy services for medication reconciliation, educating patients on prescribed therapy, and medication management can significantly improve treatment outcomes during the transition of care. The aim of this research was to develop a protocol for counseling cardiovascular patients about the prescribed at hospital discharge and to pilot and evaluate it in order to make recommendations for further research. The study was designed as a prospective intervention study with two parallel groups and randomization adapted to the research conditions. The research was conducted at the Institute for Cardiovascular Diseases of the "Sveti Duh" Clinical Hospital. During the development of the protocol, the relevant literature was searched on the topic of counseling patients at discharge from the hospital, and the concepts of pharmaceutical care practice, according to Cipolle et al., were taken into account. All subjects filled out a short questionnaire about their health state, medication history and their understanding of the prescribed therapy. During counseling, special emphasis was placed on the individual’s identified needs and insecurities, and an effort was made to establish a good therapeutic relationship, as it is the foundation of pharmaceutical care, and as part of the counseling, each subject was given a written leaflet containing the most important information about each medication in the therapeutic regimen. 30 days after discharge from the hospital, all subjects were contacted by telephone for a follow-up questionnaire with the aim of assessing their adherence, utilization of health care and their self-rated health. The study included 99 subjects with a median age of 70 years and an interquartile range between 63 and 75 years, with an average of 10,91 ± 3,51 drugs prescribed at hospital discharge. No statistically significant difference in adherence was found between the intervention and control groups at any point of the study (p= 0,059 at the interview in the hospital and p= 0,305 at the telephone follow-up). For the intervention group, no statistically significant difference was found between the different points of examination (p = 0,383), while for the control group there was a statistically significant difference (p = 0.039). A statistically significant difference was also not shown for the utilization of health care between the intervention and control groups (p = 0,568 for emergency room admissions, p = 0,603 for the number of days spent in the hospital and p = 0,202 for visits to the family medicine physician) and for the assessment of self-reported health between the intervention and control group (p = 0,266). Respondents in the intervention group notice a bigger improvement in their own health with a statistically significant difference compared to the control group (p = 0.036). Most subjects in the intervention group stated that the provided counseling service helped them a lot in understanding their therapy, which shows that the developed protocol succeeds in establishing a good therapeutic relationship and in optimizing the patient's therapeutic experience. These results, together with the researcher's experience during piloting of the protocol, show that there is a need for educating patients about their therapy at hospital discharge, especially for patients with the highest risk of unplanned rehospitalization. In order to integrate this protocol into clinical practice, further research need to be conducted with a larger number of subjects, computer generated randomization and longer monitoring of subjects with more follow-up counsellings.