The aim of this study was to identify and determine the incidence of drug therapy problems in hospitalized patients with type 2 diabetes. A cross-sectional observational study was conducted in the period from September 1st to October 15th 2015 at the Clinic for Internal Medicine, University Hospital Dubrava in the departments of gastroenterology and endocrinology. Patients included in the study were admitted via emergency or elective admission to the departments of the Clinic. Inclusion criteria for all patients who participated in this study were the presence of type 2 diabetes in primary diagnosis or as a comorbidity and a singned informed consent. The data collection process was performed primarily through interviews with patients who were hospitalized in the departments of the Clinic using a standardized questionnaire (Appendix 2), which was designed specifically for the needs of this research. It included several categories of questions that provided detailed insight into the patient's health status, medication history and current pharmacotherapy. The data were also collected by examining the temperature charts, medical records available in the departments and the hospital information system (BIS), consultations with physicians and other medical personel and interviews with relatives and/or carriers of the patients if needed. Approval for the conduction of this study was granted by the Ethics Committee of the Clinical Hospital Dubrava. The study included a total of 76 subjects (39 men and 37 women). The average age of patients was 66.7 ± 10.6 years (range 43 - 87). The patients had an average of 3.14 ± 7.63 diagnoses (in the range of 1 to 17, a total of 580 recorded in the study). A total of 653 medicines was proscribed, with the average of 8.59 ± 3.24 (range 3 - 17) per patient. Total number of drug therapy problems identified by Cipolle's tools for the identification and description of the drug therapy problems was 376, or 4.94 ± 3.86 therapeutic problems per patient. It was found that the largest number of identified therapeutic problems were related to the category of unnecessary medication (N=72) and category related to the requirement of additional medication (N=72). The third most common kind of therapeutic problem was too low dose (N=68). This study showed a high incidence of drug therapy problems in the population of hospitalized patients with type 2 diabetes. In order to reduce this, it is necessary to actively work on a system that implies a multidisciplinary approach to patients and focuses on their therapeutic needs and problems. Only this kind of approach allows achieving the most desired therapeutic outcomes and provides the best medical care for patients there is.