Last decades we have witnessed intense changes in the pharmacy profession which is the reason for the development of competencies in pharmacy imposed as one of the basic prerequisites for the provision of pharmaceutical care as well as improving therapeutic outcomes and patients quality of life. Therefore, competency frameworks which prompt personal and professional development have become an important component of lifelong learning and are driven by the need for development and professional recognition of healthcare professionals. Objectives: The aim of this study was to define competencies that need to be developed in clinical pharmacists with an aim of improving pharmaceutical care. Additionally, aim was to assess competencies of community pharmacists-preceptors using Croatian Competency Framework (CCF). Subjects and methods: This observational prospective study has included so-called community pharmacists-preceptors or community pharmacists who have voluntarily accepted invitation of Faculty of Pharmacy and Biochemistry to provide support and mentoring to students-trainees within Pre-registration training of pharmacy students. Mentioned community pharmacists-preceptors have attended education at Faculty of Pharmacy and Biochemistry in October 2015. and February 2016. where they had an opportunity to meet with the Pre-registration training of pharmacy students Program, based on CCF. Community pharmacists-preceptors assessed their competencies at starting point of time, before involving into the program of Pre-registration training of pharmacy students and delivered their self-assessments by e-mails afterwards. Data were collected using CCF, validated toll for assessment and self-assessment of community and hospital pharmacists, during the period from October 2015. until April 2016. Results: Of the total of 260 community pharmacists invited in this study, final analysis included 223 respondents (F: 204; M: 19) from 168 community pharmacies. The response rate was 85,8 %. The median age of the respondents was 41 year (range 27 - 65) and a median of service spent in a community pharmacy was 14 years (range 2 - 40). Community pharmacists-preceptors assessed themselves as the most competent in competencies from the cluster „Organizational and management competencies” (3.64 ± 0.336), while they considered themselves at least competent for the competencies from the cluster „Pharmaceutical public health competencies”(2.75 ± 0.769). Highest score was assessed for the competency „Professional and ethical practice” (3.77 ± 0.393), while the lowest score was recorded for competency „Ensuring the safe application of medicines” (2.62 ± 0.685). Conclusion: This research represents first testing of the CCF in practice as a valuable tool in assessment and self-assessment of pharmacists competencies. Analyzing collected data identified competencies that need to be improved in community pharmacist with an aim of improving the quality of pharmacists interventions in community pharmacies. Consequently, areas in which community pharmacist in our country require additional professional education are defined.