Cardiovascular diseases are the main cause of death and the reason for hospital treatment in Croatia. Nearly every second resident of the country dies because of these diseases. Numerous studies have shown the association between platelets and hyperlipidemia with initiation and complication of atherosclerotic lesions and recent studies have also shown the role of erythrocytes in the atherosclerotic process. The aim of this study was to examine the correlation between blood lipid levels with platelet and erythrocyte indices and to assess whether their roles of risk factors are independent. The correlation was tested in the group of patients with essential hypertension and in the heterogeneous group of randomly selected patients. Thereafter, findings between these two groups were compared. In the heterogeneous group of patients, statistically significant, but poor correlation between erythrocyte indices and lipids was found. It refers to the association of RDW and LDL-cholesterol, RDW and total cholesterol, MCV and LDL-cholesterol, and MCV and total cholesterol. In the group of patients with essential hypertension, statistically significant, but poor correlation between erythrocyte indices and total cholesterol was found. We haven't found correlation between platelet indices and lipid parameters in any of the groups. Furthermore, no statistically significant difference was found by comparing hematologic and lipid parameters between the examined groups. In patients with essential hypertension, good and statistically significant positive correlation between age and lipids (total cholesterol, LDL-cholesterol, triglycerides) was found. This suggests that lipids are significant and independent risk factor in these patients and that increase in age in patients with hypertension contributes to the cardiovascular risk.