The skin as an organ is a physical barrier but it also has chemically and immunologically defined defensive properties. Skin also harbors microbiota. Besides the widely studied microbial communities such as the gastro-intestinal tract and the vaginal epithelia, the skin microbiome is also an interesting target of scientific research. In this thesis we shall discuss skin microbiome properties, the diversity of microbiota on the skin (bacteria, archaea and eukaryotic cells) and their role in eubiosis. The discussion will be especially focused on explaining the diversity of microbiota in the armpit (axillae) and their role in the occurrence of unpleasant body odor with the goal of reducing that odor. The next focus of the present thesis will be on the use of antiseptics (as biocides) on the skin of the hands with the goal of reducing the microbial population (resident or transient) as well as the major role of washing hands in public health. Taking into account resident and transient microbiota on the skin of the hands, the use of antiseptics has a major impact on the spreading of multiple-resistant microbial species via hands, which is an important public health issue.