Osteoarthritis is a chronic inflammatory joint disease characterized by degeneration of the joint cartilage and surrounding bone, which can cause pain and stiffness and thus a certain degree of disability of the patient.Treatment of osteoarthritis is symptomatic where pharmacological therapy involves the use of paracetamol, opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and intra-articular injections of corticosteroids and hyaluronic acid. The disadvantage of mentioned therapy is the contraindication of NSAIDs in patients manifesting in the gastrointestinal system. Corticosteroids, though potent anti-inflammatory drugs, can cause joint damage when frequently used. That is why new concepts for osteoarthritis are being introduced and nutraceuticals are mentioned as one of the alternatives. Nutraceuticals have a high potential in treating osteoarthritis due to their potential efficacy and a good safety profile, which is the main advantage of using such products. Curcumin, the main active turmeric ingredient, is a pleiotropic molecule with an excellent safety profile and proven potency in inflammatory diseases such as osteoarthritis where it acts as anti-inflammatory agent and as an antioxidant. Although natural curcumin has limited therapeutic efficacy due to poor solubility and low bioavailability, most clinical trials investigate the therapeutic efficacy of formulations with improved bioavailability. Further clinical studies may contribute in defining optimal therapeutic guidelines for the use of curcumin in osteoarthritis in order to improve pharmacological care of patients suffering from this disease.