In integrated plant protection, there is often a need to control pests at the same time using chemical agents and natural enemies. In such cases, it is extremely important to know the effect of individual insecticides on as many natural enemies as possible. The predatory bug Macrolophus pygmaeus Rambur is used to control shield moths, thrips, nettle mites, aphids and other significant pests in the greenhouse production of fruit-bearing vegetables. The aim of this work was to determine the direct and residual (1, 3 and 7 days after treatment) toxicity of insecticides based on the active substances azadirachtin, spinosad, pyrethrin, lambda-cyhalothrin, acetamiprid, abamectin and lufenuron applied in three concentrations to the predatory bug Macrolophus pygmaeus. The hypothesis is that the sensitivity of the Macrolophus pygmaeus species depends on the type of insecticide and the applied concentration, where the sensitivity is the highest during direct treatment, and in the case of the release of mirids on treated plants, the sensitivity increases with the increase in the concentration of the applied insecticide, while it decreases with the passage of time that has passed from treatment to exposure of mirids to insecticide. The results showed that direct insecticide contact has a stronger impact than residual one, while the residual impact decreases with the age of the insecticide deposit. The effect of the insecticides in both experiments increased with the passage of time after the exposure of the mirids to the insecticides. The differences in the concentrations of insecticides weren’t significant.