Muscular dystrophies are a group of inherited disorders characterized by progressive weakening and degeneration of muscles. Considering the contractile force they produce and to which they are exposed, muscle cells need to be secured against mechanical damage. In that sense, the structural linkage between the cytoskeleton and the extracellular matrix is of utmost importance, because it keeps the plasma membrane of muscle cells (sarcolemma) stable. Said linkage is achieved through transmembrane proteins, primarily integrins, and the dystrophin-glycoprotein complex (DGC). On one side of the sarcolemma, they bind elements of the cytoskeleton and on the other, laminin, an importat component of the extracellular matrix of muscles. The interactions of the nuclear envelope with the cytoskeleton and the nuclear lamina are also important for the stability of muscle cells. They determine the structural integrity of the nucleus as well as the genetic stability of the cell. Accordingly, disturbances along the line: extracellular matrix – sarcolemma – cytoskeleton – nuclear envelope – nuclear lamina – chromatin, compromise the durability of muscle cells and can lead to the development of muscular dystrophies. Therapeutic approaches to these disorders are mostly aimed at restoring the expression and increasing the functionality of defective proteins.