Mesolimbic dopamine pathway is one of the four main dopamine pathways. It connects ventral tegmental area, where dopamine is created, and nucleus accumbens in striatum. After dopamine secretion, it binds to G protein-coupled receptor. This does not directly lead to the creation of an action potential by opening ion channels, rather it activates a signaling pathway inside the neuron, which changes cellular activity, through which a change in ion receptors occurs. Dopamine is constantly secreted from dopaminergic neurons, when reward occurs, the release changes, thus learning about rewarding stimuli. In the case of a higher-than-expected reward, more dopamine is secreted, and when the reward is smaller, dopamine secretion is inhibited. Furthermore, dopamine secretion in the mesolimbic pathway generates wanting for reward, and slower secretion generates motivation. Addiction is one of the biggest health problems nowadays, and mesolimbic dopamine pathway is essential for its emergence. Each drug that causes addiction affects secretion of dopamine within the mesolimbic dopamine pathway because it determines how much wanting for reward is generated. During addiction, the most important change within mesolimbic neurons is the change in the dopamine receptors ratio. Mesolimbic dopamine plays a role in the creation of depression, ADHD and, schizophenia.