prikaz prve stranice dokumenta Wireless optoelectronic devices for vagus nerve stimulation in mice
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Wireless optoelectronic devices for vagus nerve stimulation in mice
Journal of Neural Engineering, 19 (2022), 6; 066031. https://doi.org/10.1088/1741-2552/aca1e3
Donahue, Mary J; Ejneby, Malin Silverå; Jakešová, Marie; Caravaca, April S; Andersson, Gabriel; Sahalianov, Ihor; Đerek, Vedran; Hult, Henrik; Olofsson, Peder S; Głowacki, Eric Daniel

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Institucijski repozitorij: Repozitorij Prirodoslovno-matematičkog fakulteta

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Donahue, M. J., Ejneby, M. S., Jakešová, M., Caravaca, A. S., Andersson, G., Sahalianov, I. ... Głowacki, E. D. (2022). Wireless optoelectronic devices for vagus nerve stimulation in mice. Journal of Neural Engineering, 19. (6). doi: 10.1088/1741-2552/aca1e3

Donahue, Mary J, et al. "Wireless optoelectronic devices for vagus nerve stimulation in mice." Journal of Neural Engineering, vol. 19, br. 6, 2022. https://doi.org/10.1088/1741-2552/aca1e3

Donahue, Mary J, Malin Silverå Ejneby, Marie Jakešová, April S Caravaca, Gabriel Andersson, Ihor Sahalianov, Vedran Đerek, Henrik Hult, Peder S Olofsson i Eric Daniel Głowacki. "Wireless optoelectronic devices for vagus nerve stimulation in mice." Journal of Neural Engineering 19, br. 6 (2022). https://doi.org/10.1088/1741-2552/aca1e3

Donahue, M. J., et al. (2022) 'Wireless optoelectronic devices for vagus nerve stimulation in mice', Journal of Neural Engineering, 19(6). doi: 10.1088/1741-2552/aca1e3

Donahue MJ, Ejneby MS, Jakešová M, Caravaca AS, Andersson G, Sahalianov I, i sur.. Wireless optoelectronic devices for vagus nerve stimulation in mice. Journal of Neural Engineering [Internet]. 09.12.2022. [pristupljeno 26.03.2025.];19(6). doi: 10.1088/1741-2552/aca1e3

M. J. Donahue, et al., "Wireless optoelectronic devices for vagus nerve stimulation in mice", Journal of Neural Engineering, vol. 19, br. 6, Prosinac 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:464039. [Citirano: 26.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:217:464039
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Naslov (engleski)Wireless optoelectronic devices for vagus nerve stimulation in mice
AutorMary J Donahue
AutorMalin Silverå Ejneby
AutorMarie Jakešová
AutorApril S Caravaca
AutorGabriel Andersson
AutorIhor Sahalianov
AutorVedran Đerek
AutorHenrik Hult
AutorPeder S Olofsson
AutorEric Daniel Głowacki
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Sažetak (engleski)
Objective. Vagus nerve stimulation (VNS) is a promising approach for the treatment of a wide variety of debilitating conditions, including autoimmune diseases and intractable epilepsy. Much remains to be learned about the molecular mechanisms involved in vagus nerve regulation of organ function. Despite an abundance of well-characterized rodent models of common chronic diseases, currently available technologies are rarely suitable for the required long-term experiments in freely moving animals,... Više particularly experimental mice. Due to challenging anatomical limitations, many relevant experiments require miniaturized, less invasive, and wireless devices for precise stimulation of the vagus nerve and other peripheral nerves of interest. Our objective is to outline possible solutions to this problem by using nongenetic light-based stimulation. Approach. We describe how to design and benchmark new microstimulation devices that are based on transcutaneous photovoltaic stimulation. The approach is to use wired multielectrode cuffs to test different stimulation patterns, and then build photovoltaic stimulators to generate the most optimal patterns. We validate stimulation through heart rate analysis. Main results. A range of different stimulation geometries are explored with large differences in performance. Two types of photovoltaic devices are fabricated to deliver stimulation: photocapacitors and photovoltaic flags. The former is simple and more compact, but has limited efficiency. The photovoltaic flag approach is more elaborate, but highly efficient. Both can be used for wireless actuation of the vagus nerve using light impulses. Significance. These approaches can enable studies in small animals that were previously challenging, such as long-term in vivo studies for mapping functional vagus nerve innervation. This new knowledge may have potential to support clinical translation of VNS for treatment of select inflammatory and neurologic diseases. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Neural Engineering
Brojčani podacivol. 19, br. 6, 066031
p-ISSN1741-2560
e-ISSN1741-2552
DOIhttps://doi.org/10.1088/1741-2552/aca1e3
URN:NBNurn:nbn:hr:217:464039
Datum objave publikacije2022-12-09
URL dokumentahttps://iopscience.iop.org/article/10.1088/1741-2552/aca1e3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomenaOriginal content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Received 27 may 2022. Revised 26 october 2022. Accepted for publication 10 november 2022. Published 9 december 2022.
Datum i vrijeme pohrane2024-08-03 18:06:07
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