The paper analyzes the population of Međimurje from 2011 to 2021 based on its natural, mechanical and general movement and structural features. It tries to interpret the most important demographic trends present in that period and to observe changes in the structure of the Međimurje population. Data from the 2011 and 2021 Census of Population and the annual announcements of the Croatian Bureau of Statistics were used as the main data sources. The data show that Međimurje was affected by depopulation in the observed period, which was largely the result of a very negative migration balance. It is largely a consequence of Croatia´s accession to the European Union in 2013. Međimurje has also recorded a negative natural change, but it is still significantly less intense than the Croatian average. The extremely high birth rates of the Roma population play a big role in this. Taking into account the fact that the natural decline is becoming more and more pronounced and that the share of the old population has significantly exceeded the share of the young, the need for a well-thought-out implementation of the prenatal population policy arises. The structure of the Međimurje population in 2021 has changed to a certain extent compared to 2011, depending on the feature observed, and it also points to the uniqueness of Međimurje in many of these features compared to Croatia as a whole.