As the area with the greatest concentration of people and human activities, the city has the leading role in the development of the wider area. In the introductory part, policies and measures were explored in depth, with an emphasis on city region planning. Strategic documents at all administrative levels represent an essential source. The Mechanism of Integrated Territorial Investments (ITU) is an example of the regional development policy of city regions, in which the city and its surroundings jointly adopt a development strategy and implement development projects. To carry out the case study, a detailed analysis of the geographical and development characteristics of the Urban Agglomeration (UA) of Osijek was carried out, emphasizing demographic, functional, and traffic characteristics. In addition, a survey was conducted in which the views and opinions of 350 respondents were collected about the current state, the possibilities, and limitations of the future development of the UA Osijek. It was established that there are certain differences in quality of life satisfaction and attitudes regarding future development between the city, the immediate, and wider surroundings. Finally, model of the development axis of the UA Osijek was formed. The axes extend radially from the center towards the regional centers of the Osijek region in five directions - the Baranja axis, the Vukovar axis, the Vinkovci axis, the Đakovo axis, and the Podravina triangle.