Low Neretva region is specific geographical region in Republic Croatia. Ecological, hydrological and agricultural importance for the area has for its natural geographical components. Alluvial plain, karst area, the Neretva River, plenty of water, the Mediterranean climate, fertile soil, originally wetlands, biodiversity and protected natural areas are just some of them. Low Neretva region is in constant demographic growth thanks to the growth of the urban population while the population of the municipalities is in the fall. The economy is in trouble. It is oriented to intensive agriculture, which still does not realize all the potential and seriously threatens to the environment. If Low Neretva region experienced demographic and economic growth the use of natural resources must be sustainable. The aim of this master thesis is to analyze the sustainable development with a focus on economic potentials which are not harmful to the environment. The environmental component of sustainable development is seen through the DPSIR model in order to identify the causes and sources of pressure on the environment and find ways to solve environmental problems in order to develop region on sustainable way.