In this diploma thesis, chalcone and five of its derivatives with different substituents at different positions of benzene rings were obtained: 3-(4-dimethylaminophenyl)-1-phenylprop-2-en-1-one, 3-(2,4,6-trimethylphenyl)-1-phenylprop-2-en-1-one, 1-(2,4,6-trimethylphenyl)-3-phenylprop-2-en-1-one, 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one and 1-(2,4,6-trimethylphenyl)-3-(2,4,6-trimethylphenyl)prop-2-en-1-one. The compounds were prepared in two ways: Claisen-Schimdt condensation in solution using ultrasounic waves and mechanochemical synthesis (with catalytic solvent addition). The synthesis of oximes of prepared chalcones has been carried out, with only two oximes successfully purified: 1,3-diphenylprop-2-en-1-one oxime and 3-(2,4,6-trimethylphenyl)-1-phenylprop-2-en-1-one oxime. The compounds were prepared by reaction of the corresponding chalcones and hydroxylammonium chloride. Mechanochemical synthesis chalcone oxime with the addition of various organic bases (pyridine, imidazole, 4-dimethylaminopyridine (DMAP) and 1,4-diazobicyclo[2.2.2]octane (DABCO)) did not prove to be a good method for their synthesis. Melting point of synthetised compounds were determined and they were analyzed by spectroscopic methods: IR spectroscopy and 1H NMR and 13C NMR spectroscopy. Signal ratio of chalcones oximes in 1H NMR spectra determined that E and Z isomers were present in the mixture.