Reactive oxygen species (ROS) are associated with development of oxidative stress that damages cellular macromolecules and are often set in connection with various diseases. Various and many factors lead to formation of ROS. Changes in the levels of malondialdehyde (MDA), protein carbonyl and glutathione (GSH) are just some of the indicators that point to oxidative stress. The aim of this study was to examine whether there is a significant difference in the concentration of the referred indicators of oxidative stress in subjects occupationally exposed to microwave radiation. Research was conducted on the samples of whole blood of subjects occupationally exposed to microwave radiation of radar frequency range of 1,5 GHz to 10,9 GHz, within microwave field of 10 μW/cm2 to 10 mW/cm2, while the control group was made of employees of Institute for Medical Research and Occupational Health. Concentrations of GSH and protein carbonyls were measured by spectrophotometric method, while MDA concentrations were measured using HPLC technique. Gained concentrations were in reference to the concentration of total protein, and the difference between control and exposed group was shown by Student's t-test for independent samples. Statistical analysis shown significant difference in the values of GSH and MDA concentrations between exposed and control group, while the difference among protein carbonyls were not observed. These results indicate a possible link between microwave radiation and the formation of ROS and the appearance of oxidative stress.