Muramyl dipeptide (MDP), N-acetylmuramyl-L-alanyl-D-isoglutamine, is the fragment of peptidoglycan which added to vaccines prolongate or enhance a specific immune response to a specific antigen. Since MDP can not be clinically used because side effects such as pyrogenic activity, numerous MDP derivatives and analogues with improved pharmacological properties were synthesized, including derivatives without sugar part known as desmuramydipeptides. Furthermore, mannose analogues of MDP have showed better adjuvant activity, probably due to interactions of mannose with mannose receptors present on immunocompetent cells. In the scope of this Diploma Thesis novel desmuramylpeptide mannocojugates with potential adjuvant activity were synthesized. Desmuramylpeptide mannoconjugates have different groups (hydroxy, adamantyl, adamantyl triazole) attached to carboxy group in C-terminus. First 2-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)acetic acid was synthesized. The bromine in tert-butyl bromoacetate was substituted with the 2,3,4,6-tetra-O-acetyl-α-D-mannopyranose. Ester group of the prepared O-mannoside was hydrolyzed and obtained carboxylic acid was then coupled to corresponding desmuramyldipeptide derivative using EDC / HOBt carbodiimide method. In the last step protective groups from mannose were selectively removed. All the synthesized compounds were characterized by NMR spectroscopy and mass spectrometry, and some of them were additionaly analyzed by IR spectroscopy.