Moray eel (Muraena helena L.) is a Mediterranean species of fish known from ancient times, interesting from a biological and commercial point of view, and due to its benthic and perennial lifestyle, sedentary lifestyle, limited migration rate along with growth rate and consumption of a wide range of species in different trophic positions, this species could be an interesting potential bioindicator for studying benthic heavy metal pollution in the Adriatic / Mediterranean. This paper shows how the major residual metals accumulate within different organs of this species. Moray eels were collected in the unpolluted area of the Adriatic Sea, Elafiti-Dubrovnik in summer and winter period. The aim of the work is to show the bioaccumulation potential of different organs for metals Hg, As, Cd, Pb and to determine which would be best for the bioindicative potential for the accumulation of metals from the marine environment. In most organs, except the heart, the highest bioaccumulation occurs during the summer. Exceptionally, in winter, mercury and arsenic accumulate most only in muscle tissue. Of all the metals studied, if we look at all collected samples regardless of season, mercury is the most represented accumulated metal in all organs except heart and skin. The skin mostly accumulates lead. Arsenic is the second most abundant metal present in most organs except liver and gills (in gills lead is equally abundant by percentage). Although lead is the third largest in all organs (except gills), the percentage concentration relative to other metals is not negligible and is relatively high. The highest average concentrations reached for mercury are about 0.5 mg/kg in the liver and about 0.25 mg/kg in the bones, for arsenic about 0.2 mg/kg in the gills, for lead about 0.175 mg/kg in the bones and for cadmium 0.25 mg/kg in the skin.