The presence of disability results in a higher probability that people with disabilities will be at risk of human rights violations more than people without disabilities, that was the main reason why the United Nations adopted the Convention on the rights of persons with disabilities which was ratified by Croatia on first of June 2007 . The aim of our work is to analyze the difficulties which persons with disabilities are faced in the Republic of Croatia in exercising their rights guaranteed by the Convention. Based on the conducted analysis, we conclude that, after the ratification of the Convention, certain improvement have been made in the legislation, but also in the practical application rights of persons with disabilities in many areas accessibility, employment, legal capacity, political participation. It is also important to point out that we have noticed a lot of space for progress in the implementation of most articles of the Convention, particularly those concerning the harmonization of national regulations with the provisions of the Convention on Inclusive Education, Employment, Accessibility and Social Protection we also consider them the most important to achieve full inclusion of persons with disabilities in the Croatian society. We consider that the branch of social policy plays a key role in improving the application of the Convention on the rights of persons through the amendments on relevant legislative regulations in accordance with the Convention and the adoption of quality programs and strategies that will in a professional way contribute significantly to the practical implementation of the Convention.