The use of spirituality and religiosity in social work is possible with a multitude of user groups. Some of the approaches applied in professional social work are bibliodrama, mindfulness, meditation, prayer and hagiotherapy. The benefits of applying these approaches are manifold; they tend to strengthen the mutual trust of the user and the social worker, the user is empowered and gets a sense of meaning in moments of difficulties in life and overcomes them more easily. Spirituality and religiosity are especially important in working with some user groups, such as recovering addicts, people with disabilities, the elderly and people with mental disorders. In addition to use of those approaches in direct work with users, they can be applied in the supervision of social work, and as such constitute important resource for empowering social workers, and on the other hand, support the social worker in understanding user worldviews and spiritual beliefs. The personal spirituality and religiosity of social workers is also an important factor that gives social workers strength and motivation and offers users environment to work on the spiritual dimension in an atmosphere of acceptance and respect.