Mothers are one of the vulnerable groups during the COVID-19 pandemic. Due to the increased range of responsibilities and roles during a pandemic and exposure to daily stressors, mothers are at the risk of parental stress and mental health problems. The aim of this study was to determine the level of perceived parental stress and the levels of depression, anxiety and stress of mothers, their interrelationship, and their relationship to mothers’ experience with coronavirus and sociodemographic characteristics. 224 mothers of minor children participated in the research, and the data were collected through an online survey. The results showed a statistically significant positive association between the experienced level of parental stress and the level of depression, anxiety, and stress. In addition, there is a statistically significant positive association between the experience of coronavirus infection and levels of depression, anxiety and stress. Mothers infected with the coronavirus have higher levels of anxiety and depression. The study also showed a statistically significant positive correlation between anxiety and the experience of parenting demands during a pandemic, as well as a statistically significant positive correlation between stress levels and the amount of conflict with children during a pandemic. Mothers who found parenting more difficult during the pandemic than before showed a higher amount of conflict with their children.